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20 juin 2017

Le 20 Juin 2017

Préparées par Jean-François Etter

Sommaire:
• Philip Morris demande à l'Université de Lausanne de ne plus diffuser un article scientifique défavorable à sa cigarette Iqos
• Une nouvelle technologie de vaporisation fournit un apport rapide de nicotine
• Electronic cigarette: a longitudinal study of regular vapers

Philip Morris demande à l'Université de Lausanne de ne plus diffuser un article scientifique défavorable à sa cigarette Iqos

C'est ce qu'a révélé jeudi lors d'une conférence le doyen de la faculté de biologie et de médecine, Jean-Daniel Tissot. Lire l'article:

http://www.lenouvelliste.ch/articles/suisse/philip-morris-attaque-une-etude-677015

Drôle de façon de participer au débat scientifique: mettre la pression sur l'Université quand une étude est contraire aux intérêts de l'industrie ...


Une nouvelle technologie de vaporisation fournit un apport rapide de nicotine

Une nouvelle technologie de vaporisation (lactate de nicotine) permet un apport substantiel et rapide de nicotine.

Conclusions de cette étude de PMI: Aux trois niveaux de nicotine testés, l'inhalation de l'aérosol de lactate de nicotine livré avec le P3L a fourni des concentrations plasmatiques de nicotine plus élevées et plus rapides par rapport à l'inhalateur de Nicorette. Le profil de concentration-temps de nicotine plasmatique soutient une voie d'absorption pulmonaire pour P3L par rapport à l'absorption oromucosale de l'inhalateur Nicorette.

https://academic.oup.com/ntr/article-lookup/doi/10.1093/ntr/ntx093

Evaluation of Nicotine Pharmacokinetics and Subjective Effects following Use of a Novel Nicotine Delivery System

Nicotine Tob Res ntx093. DOI: https://doi.org/10.1093/ntr/ntx093

Published: 06 May 2017

Author information
1 Philip Morris Products S.A., Research & Development, Neuchâtel, Switzerland.
2 Christchurch Clinical Studies Trust Ltd., Christchurch, New Zealand.
3 Health New Zealand Ltd., Christchurch, New Zealand.


Electronic cigarette: a longitudinal study of regular vapers

Introduction.
It is unclear how vaping behaviour changes over time in regular vapers, and what occurs when vapers relapse to smoking or when they stop vaping. We assessed change in vaping and smoking behaviours over 12 months in regular vapers.

Methods.
A longitudinal study of 3868 regular vapers enrolled on the Internet in 20122015 (baseline), followed after one (n=1631, 42%), three (n=1337, 35%), six (n=1148, 30%) and 12 months (n=893, 23%).

Results.
Participants had been vaping for a median of five months at baseline. Most (77%) were former smokers, who had not smoked for a median of three months at baseline. Over 12 months, enjoyment gradually became the most frequently cited reason to vape (93%), and vaping to deal with craving for tobacco gradually decreased (from 87% to 56%). In exclusive vapers (ex-smokers), nicotine concentration in e-liquids decreased over time (from 12 to 9 mg/mL), but puffs/day remained stable (200 puffs/day). After 12 months, 9% of 687 former smokers relapsed to smoking and 28% of 64 daily smokers (dual users) stopped smoking. After 12 months, when participants stopped vaping, they tended to relapse to smoking (+18% daily smokers among those who stopped vaping versus -2% in permanent vapers, p<.001). When ex-smokers relapsed to smoking, they tended to stop vaping.

Conclusions.
After 12 months, enjoyment and relapse prevention were the most important reasons to vape. Rates of relapse to smoking were low in former smokers and quit rates were high in current smokers. Stopping vaping was associated with relapsing to smoking.

Implications.
Even in established vapers, vaping behaviour and reasons to vape change over time. This should be taken into account by clinicians, manufacturers and regulators. Results from this non-representative sample can help generate hypotheses that can later be tested in representative samples of vapers.

Abstract:
https://academic.oup.com/ntr/article-abstract/doi/10.1093/ntr/ntx132/3861935/Electronic-cigarette-a-longitudinal-study-of
Article (free access):
https://academic.oup.com/ntr/article/doi/10.1093/ntr/ntx132/3861935/Electronic-cigarette-a-longitudinal-study-of?guestAccessKey=0dd28ab2-b9fa-450f-9734-e2cb15f6a62f
Jean-François Etter, PhD
Nicotine & Tobacco Research. June 2017.
DOI: https://doi.org/10.1093/ntr/ntx132

et voir aussi le blog de Jean-Yves Nau :

https://jeanyvesnau.com/2017/06/12/e-cigarette-nen-deplaise-a-tabac-info-service-elle-aide-vraiment-a-arreter-de-fumer/?preview_id=35557&preview_nonce=b17ba8f9ad

et aussi le blog de Philippe Poirson:

https://vapolitique.blogspot.ch/2017/06/expresso-suivi-long-terme-la-vape-outil.html



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