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30 décembre 2014

Nouvelles sur le tabagisme de Stop-tabac.ch
Préparées par Jean-François Etter
Le 30 Décembre 2014


- La cytisine plus efficace que la nicotine pour arrêter de fumer
- La cigarette électronique calmerait l'envie de fumer
- Merci à Grégoire Monney et Felicia Schmid, bienvenue à Evelyne Laszlo
- E-cigarettes at mercy of bureaucrats who ban by default
- Fasting for three days renews entire immune system, protects cancer patients
- Chattez avec un médecin tabacologue

La cytisine plus efficace que la nicotine pour arrêter de fumer

Background Placebo-controlled trials indicate that cytisine, a partial agonist that binds the nicotinic acetylcholine receptor and is used for smoking cessation, almost doubles the chances of quitting at 6 months. We investigated whether cytisine was at least as effective as nicotine-replacement therapy in helping smokers to quit. Methods We conducted a pragmatic, open-label, noninferiority trial in New Zealand in which 1310 adult daily smokers who were motivated to quit and called the national quitline were randomly assigned in a 1:1 ratio to receive cytisine for 25 days or nicotine-replacement therapy for 8 weeks. Cytisine was provided by mail, free of charge, and nicotine-replacement therapy was provided through vouchers for low-cost patches along with gum or lozenges. Low-intensity, telephone-delivered behavioral support was provided to both groups through the quitline. The primary outcome was self-reported continuous abstinence at 1 month. Results At 1 month, continuous abstinence from smoking was reported for 40% of participants receiving cytisine (264 of 655) and 31% of participants receiving nicotine-replacement therapy (203 of 655), for a difference of 9.3 percentage points (95% confidence interval, 4.2 to 14.5). The effectiveness of cytisine for continuous abstinence was superior to that of nicotine-replacement therapy at 1 week, 2 months, and 6 months. In a prespecified subgroup analysis of the primary outcome, cytisine was superior to nicotine-replacement therapy among women and noninferior among men. Self-reported adverse events over 6 months occurred more frequently in the cytisine group (288 events among 204 participants) than in the group receiving nicotine-replacement therapy (174 events among 134 participants); adverse events were primarily nausea and vomiting and sleep disorders. Conclusions When combined with brief behavioral support, cytisine was found to be superior to nicotine-replacement therapy in helping smokers quit smoking, but it was associated with a higher frequency of self-reported adverse events. (Funded by the Health Research Council of New Zealand; Australian New Zealand Clinical Trials Registry number, ACTRN12610000590066 .).

N Engl J Med. 2014 Dec 18;371(25):2353-2362.
Cytisine versus Nicotine for Smoking Cessation.
Walker N1, Howe C, Glover M, McRobbie H, Barnes J, Nosa V, Parag V, Bassett B, Bullen C.
http://www.ncbi.nlm.nih.gov/pubmed/25517706

N Engl J Med. 2014 Dec 18;371(25):2429-2430.
Cytisine - A Tobacco Treatment Hiding in Plain Sight.
Rigotti NA1.

A randomized, controlled trial published in this issue of the Journal brings renewed attention to cytisine, a potentially useful pharmacotherapy for smoking cessation that has been hiding in plain sight.1 A naturally occurring plant alkaloid, cytisine has been sold in Eastern Europe as an inexpensive smoking-cessation aid for 50 years but is unavailable elsewhere.2 Two events brought it to broader attention in 2006. First, Etter's review2 of overlooked, older studies suggested a potential efficacy of cytisine for smoking cessation, although a firm conclusion could not be drawn because previous trials did not meet contemporary standards. Second, varenicline, a drug with ...

http://www.ncbi.nlm.nih.gov/pubmed/?term=cytisine+rigotti (18 12 2014)
(30 12 2014)


La cigarette électronique calmerait l'envie de fumer

Menée auprès de fumeurs ne désirant pas arrêter le tabac, cette nouvelle étude belge montre que la e-cigarette permettrait de réfréner le désir irrépressible de s'en allumer une. Trois groupes ont été formés de façon aléatoire : deux groupes ont été autorisés à vapoter et à fumer tandis qu'un autre ne faisait que fumer durant les deux premiers mois de l'enquête. Lire la suite: ...

http://www.sciencesetavenir.fr/sante/20141121.OBS5810/la-cigarette-electronique-calmerait-l-envie-de-fumer.html
http://www.mdpi.com/1660-4601/11/11/11220/htm
Int. J. Environ. Res. Public Health 2014, 11(11), 11220-11248;
doi:10.3390/ijerph111111220
Effectiveness of the Electronic Cigarette: An Eight-Week Flemish Study with Six-Month Follow-up on Smoking Reduction, Craving and Experienced Benefits and Complaints
Karolien Adriaens 1,, Dinska Van Gucht 1,2,, Paul Declerck 3 and Frank Baeyens 1,,* (09 12 2014)
(30 12 2014)


Merci à Grégoire Monney et Felicia Schmid, bienvenue à Evelyne Laszlo

Après 5 ans, Grégoire Monney quitte le programme Stop-tabac.ch pour passer à la pratique clinique en tant que psychologue. Grégoire a notamment créé les applis mobiles Stop-tabac, Stop-cannabis et Stop-alcool. Il a aussi aidé de nombreus visiteurs du site à arrêter de fumer, en leur prodiguant des conseils personnalisés. Nous le remercions vivement et lui souhaitons plein succès pour la suite de sa carrière.

L'étude sur les incitations financières touchant à sa fin, Felicia Schmid cesse sa collaboration avec nous. Felicia a reçu les 800 participants à cette étude avec amabilité et professionnalisme. Nous la remercions vivement et lui souhaitons plein succès pour la suite de sa carrière.

Nous souhaitons la bienvenue à Evelyne Laszlo, sociologue et psychologue, diplômée en tabacologie (Université de Paris XII), qui reprend les activités de Grégoire Monney pour Stop-tabac.ch (23 12 2014)
(30 12 2014)


E-cigarettes at mercy of bureaucrats who ban by default

It seems everything is illegal in Australia unless a bureaucrat gives permission. What's worse, you have to go to the trouble and expense of asking for permission, because if bureaucrats were proactive they would run the risk of serving the public. Read more:...

http://www.afr.com/p/opinion/cigarettes_at_mercy_of_bureaucrats_eEi8fov0QbFpWgjd136uWJ (29 07 2014)
(30 12 2014)


Fasting for three days renews entire immune system, protects cancer patients

Fasting for three days can regenerate the entire immune system, even in the elderly, scientists have found in a breakthrough described as remarkable.

Dr. Aw: Key to extending human lifespans lies in preventing chronic inflammation, research suggests Why can some people smoke a pack a day and never get lung cancer? Why do 50% of the people who get heart attacks have normal levels of cholesterol? The emerging field of epigenomics is at the heart of the biggest mysteries in medicine.

http://news.nationalpost.com/2014/06/05/fasting-for-three-days-renews-entire-immune-system-protects-cancer-patients-remarkable-new-study-finds/ (16 06 2014)
(30 12 2014)


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